The Business and Operations team from the NIHR Research Design Service (RDS) North East (NE) attended a National event for RDS Staff in London, along with other colleagues from the region. The RDS operates through regional centres to provide an integrated service across England with local focus and this was a great opportunity for us […]Read more "Research Design Service North East Head South for National Event"
I was recently lucky enough to attend the University of Cambridge’s Psychometric Centre workshop on Structural Equation Modelling (SEM) in (the statistical package) R (hence a SEMinR) to find out more about SEM and how it can be used to validate psychometric scales. SEM is a statistical technique that combines factor analysis and path analysis. […]Read more "A SEMin_R in Cambridge"
Clinical trials have been very successful in evaluating the effectiveness of new treatments. However, over recent years the cost of trials has been steadily increasing, putting pressure on limited healthcare and research resources. There is therefore a great need for novel approaches to improve the efficiency of clinical trials, avoiding research waste and reducing […]Read more "Improving the efficiency of clinical trials with adaptive designs"
Randomised controlled trials (RCTs) are the gold standard for evaluating the relative effectiveness of interventions. However, while RCTs minimise the risk of bias (systematic errors which can be introduced into projects and favour one intervention over another) and threats to internal validity (the study is performed in a way that avoids confounding), they do not […]Read more "Designing Trials that are Fit for Purpose"
What clinicians and patients want to know is not always what the existing evidence-base is equipped to say. The randomised controlled trial (RCT) is commonly regarded as the ‘gold standard’ for evaluating health interventions and findings from an RCT are used to select which interventions and treatments to implement in clinical practice. However, this is […]Read more "Developing and evaluating health interventions: Does one size fit all?"
Just how big an improvement on a scale that measures the severity of a disease is clinically meaningful? One point? Two points? Five points? And is a change from 3 to 2 equivalent to a change from 23-22? How do you go about finding out? These are the issues that I had been grappling with […]Read more "How do you specify a target difference for a clinical trial?"
What if at the touch of a button health professionals could access primary, secondary and social care records (and eventually education records)? This was the topic of the Connected Health Cities and the Great North Care Record event on 4th November in Newcastle. The Great North Care Record (GNCR) is a new system to enable […]Read more "Transforming care … transforming research?"