Clinical trials have been very successful in evaluating the effectiveness of new treatments. However, over recent years the cost of trials has been steadily increasing, putting pressure on limited healthcare and research resources. There is therefore a great need for novel approaches to improve the efficiency of clinical trials, avoiding research waste and reducing […]Read more "Improving the efficiency of clinical trials with adaptive designs"
Randomised controlled trials (RCTs) are the gold standard for evaluating the relative effectiveness of interventions. However, while RCTs minimise the risk of bias (systematic errors which can be introduced into projects and favour one intervention over another) and threats to internal validity (the study is performed in a way that avoids confounding), they do not […]Read more "Designing Trials that are Fit for Purpose"
What clinicians and patients want to know is not always what the existing evidence-base is equipped to say. The randomised controlled trial (RCT) is commonly regarded as the ‘gold standard’ for evaluating health interventions and findings from an RCT are used to select which interventions and treatments to implement in clinical practice. However, this is […]Read more "Developing and evaluating health interventions: Does one size fit all?"
Just how big an improvement on a scale that measures the severity of a disease is clinically meaningful? One point? Two points? Five points? And is a change from 3 to 2 equivalent to a change from 23-22? How do you go about finding out? These are the issues that I had been grappling with […]Read more "How do you specify a target difference for a clinical trial?"
What if at the touch of a button health professionals could access primary, secondary and social care records (and eventually education records)? This was the topic of the Connected Health Cities and the Great North Care Record event on 4th November in Newcastle. The Great North Care Record (GNCR) is a new system to enable […]Read more "Transforming care … transforming research?"
The Yorkshire & Humber Research Design Service (RDS) hosted an NIHR Invention for Innovation (i4i) Programme Event at the University of York on 1st November. It was an interesting day that really helped me better understand the i4i programme. Karen Bloor, Research Theme Champion for Health and Wellbeing, University of York, opened the day, followed […]Read more "Is impact the driver for the NIHR i4i programme?"
Why did I want to be a consumer panel member? I have been a consumer panel member for about two years now and I would not want to give it up, even although I have a busy life. I am a carer for my daughter, who has had a tough journey in her life […]Read more "All research has to have a public element"